The Lupron Overlap Protocol (Long Down-regulation Protocol), Antagonist Protocol and Poor Responder Protocol are some of the protocols used during IVF treatment. In the initial phase of IVF treatment, every woman has to go through a certain protocol.
You may hear from your doctor that the Long Down-regulation Protocol (Lupron) will be used with you. Because this protocol is used the most.
These protocols are used to stimulate a woman’s ovaries or stop ovulation, with the aim of obtaining one or more eggs to produce a healthy embryo.
You can understand it like this-
There are certain medicines under each protocol that can be given in combination to get the best results. A unique protocol is selected for each patient.
In each of the protocols, the woman is given some drug (oral or injectable). In a long down-regulation protocol, leuprolide acetate injection, commonly known as Lupron, may be given.
What is leuprolide acetate injection?
Leuprolide acetate injection or Lupron is a GnRH agonist mostly used to reduce symptoms of prostate cancer, endometriosis, and fibroids. It is also used by doctors as a fertility drug.
Lupron is used as a down regulation protocol in IVF. This medicine is given to prevent premature ovulation during ovarian stimulation procedure.
It doesn’t work right away. It takes about a week to show its effect.
How does leuprolide acetate injection work?
Lupron works in two ways. First it stimulates the pituitary gland and later suppresses this gland.
When a woman needs Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), it stimulates the pituitary gland. Then later it stops the production of these hormones by suppressing the pituitary gland.
It takes Lupron a few weeks to go from an arousal phase to a suppressed phase. That is why it is given only a few weeks before the start of other drugs.
Why is Lupron needed?
Lupron injections are usually needed for three of the following purposes:
- to suppress the pituitary gland and prevent ovulation
- As a trigger shot before egg retrieval (because the risk of ovarian hyperstimulation is lower with the Lupron trigger shot than with other fertility drugs)
- When other fertility drugs do not work properly on a woman.
Leuprolide acetate injection is usually given to a woman during a frozen embryo transfer and egg donation cycle, as ovulation needs to be stopped during this time.
Lupron is rarely used at the beginning of an IVF cycle these days. But it can act as a trigger shot in women who are at risk of ovarian hyperstimulation syndrome. In those women, leuprolide acetate injection is given instead of the HCG trigger shot.
Leuprolide Acetate Injection Side Effects
This, in a way, puts the woman’s body in a state of menopause for some time. Therefore, side effects related to menopause are seen in most women. It can be:
- body pain
- upset stomach
- hot flash
- mood swing
- Vaginal dryness and irritation
- gaining weight
- joint pain
- breast tenderness
- tingling in extremities
If you experience severe side effects, ask your doctor about this.
leuprolide acetate injection price
Lupron injections of 3.75mg can cost anywhere from ₹4,000.00 to ₹5,000.00. It has many manufacturers in India. Each company sells at a different price.
The doctor decides how many doses of Lupron injection you will take for how many days.
The main purpose of leuprolide acetate injection during the IVF cycle is to prevent continued ovulation. It is given under the Lupron Overlap Protocol. However, it is now rarely used early in the cycle.
This injection should be taken only as per the advice of the doctor. Many complications can be seen if it is consumed in the wrong method and quantity.